EFFECT OF ANTIEPILEPTIC DRUGS IN THE METABOLISM OF VITAMIN D AND ITS NEGATIVE IMPACT RELATED TO THE DEFICIT

Abstract

Actually it is known that the alteration in the
metabolism of vitamin D has been growing in
importance becoming a public health issue and it is
increasingly common the etiologies related to hormone
deficiency and its consequences in the long term, for
this reason it is necessary to conduct a detailed
description ranging from the molecular basis of
metabolism of vitamin D giving special attention to the
participation of the family enzymes that carry out its
metabolism belonging to the cytochrome P450, as well
as the description of the metabolic pathways,
interaction with the specific receptor, the genomic and
non-genomic actions of vitamin D and describe its
effects in bone metabolism and extra- skeletal role.
Later it is described the model by which medications
and especially antiepileptic drugs (AED) affect directly
the cytochrome P450 enzymes and have a negative
effect on the levels of vitamin D, bone metabolism and
thus extrapolate this concepts to the clinical practice
and help the clinician to identify patients at risk of
vitamin D deficiency and establish the risk to carry out
a consistent therapeutic approach. It should be
remembered that at the present time there isn't a
universal protocol about the clinical monitoring of
these patients even with the improvement in access to
diagnostic resources.