In this issue of the Historia y Espacio magazine, the reader will find with a dossier that was proposed and coordinated by doctors Fernando Ciaramitaro and Andrea Mutolo, and which will deal with diplomatic relations, intellectual, economic and political relations established between Mexico and Italy in a long-term perspective. In such a way, the story connected, so in vogue in our days and whose method invites us to transcend our observations beyond national borders, is the protagonist in this volume that delves into exploring both the connections and permeabilities between various worlds or cultures as the interdependencies between different scales space. On this occasion, we feel very lucky to have the participation of respected authors assigned to foreign institutions of recognized prestige that, from various perspectives and approaches, analyze the vigorous ties and interactions that, since the colonial period, have been generated between both spaces of the American and European continents.