Avances en bioingeniería dental y su aplicación en ortodoncia y ortopedia dentofacial: Una revisión de literatura.
Bioingeniería dental células madre terapia génica
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Los avances en bioingeniería dental dan a conocer la importancia de la terapia génica, celular y tisular como enfoque novedoso de la medicina regenerativa para la biomecánica ortodóntica y ortopedia dentofacial, ampliando su campo de acción, corrigiendo defectos estructurales y ofreciendo alternativas biológicas de alta calidad para la consulta especialista. Los avances en tecnología, acceso a información y exigencias actuales crean una necesidad de innovación estratégica por el clínico; el objetivo de esta revisión es describir los enfoques actuales en bioingeniería dental y terapia génica con sus aplicaciones clínicas enfocadas directamente en la consulta de ortodoncia y ortopedia dentofacial. Esto va a permitir ampliar la visión del especialista, crear necesidad de actualización constante y operar bajo evidencia científica. Se realizó una búsqueda en las bases de datos: Scopus, Medline y ScienceDirect, con las palabras clave: Bioengineering, Stem Cells, Gen Therapy. Finalmente se pudo concluir que el enfoque de la consulta odontológica va dirigido a la medicina regenerativa como terapia convencional, innovadora y de alta calidad; ofreciendo resultados con gran cercanía a la biología humana natural, eficacia a largo plazo y menor porcentaje de efectos adversos, ampliando la visión de todas aquellas fronteras en el manejo clínico del paciente.
Caicedo, C. J., & Villareal, M. P. (2017). Avances en bioingeniería dental y su aplicación en ortodoncia y ortopedia dentofacial: Una revisión de literatura. Revista Estomatologia, 25(1), 32–42. https://doi.org/10.25100/re.v25i1.6417
1. Aurrekoetxea M, Gallastegui P, Irastorza I, Luzuriaga J, Uribe V, Unda F, Ibarretxe G. Dental Pulp Stem Cells as a Multifaceted Tool for Bioengineering and the Regeneration of Craniomaxillofacial Tissues. Frontiers in Psysiology. 2015; 16(6):289.
2. Li J, Liu D, Zhang F, Wang F, Zhang W, Zhang Z. Human Dental Pulp Stem Cell is a Promising Autologous Seed Cell for Bone Tissue Engineering. Chinese Medical Journal. 2011;124(23):4022-4028
3. Yelick PC, Vacanti J. Bioengineered Teeth from Tooth Bud Cells. The Dental Clinics of North America. 2006; 50(2):191-203.
4. Wise GE, King GJ. Mechanisms of Tooth Eruption and Orthodontic Tooth Movement. Journal of Dental Research. 2008; 87(5):414-34
5. Hiroshi E, Wataru S, Masahiro N, Ikiru A,
Kentaro A. Stem Cells in Dentistry – Part I: Stem Cell Sources: Review. Journal of Prosthodontic Research. 2012;56: 151-65.
6. Hiroshi E, Wataru S, Masahiro N, Ikiru A, Kentaro A. Stem cells in dentistry – Part II: Clinical Applications: Review. Journal of Prosthodontic Research. 2012;16 :229-48.
7. Muñoz W, Trainor P. Neural Crest Cell Evolution: How and When Did a Neural Crest Cell Become a Neural Crest Cell. Current Topics in Developmental Biology. 2015; 111:3-26.
8. Noce, M; Mele, K; Tirino, V; Paino, F. Rosa, A; Naddeo, P; Papagerakis, P; Papaccio, G; Desiderio V. Neural Crest Stem Population in Craniomaxillofacial Development and Tissue Repair. European Cells and Materials. 2014; 28:348-57.
9. Mohanty P, Prasad N, Sahoo N, Kumar G, Mohanty D, Sah S. Reforming Craniofacial Orthodontics Via Stem Cells. Journal of International Society of Preventive and Community Dentistry. 2015; 5(1):13-8.
10. Parada C. Evolución y Desarrollo Facial: Perspectiva Molecular. Universitas Odontológica. 2009; 28(61): 75-85.
11. Hall BK. The Induction of Neural Crestderived Cartilage and Bone by Embryonic Epithelia: an Analysis of the Mode of Action of an Epithelial-mesenchymal Interaction. Journal of Embryology and Experimental Morphology. 1981; 64:305-320
12. Ten R. The Experimental Investigation of Odontogenesis. Journal Developmental Biology. Faculty of Dentistry. 1995; 39:5-11.
13. Kushnerev E, Yates J. Stem Cells in Dentistry – A New Era on the Horizon? Faculty Dental Journal. 2016; 7(2):64-7.
14. Mohammed S, Siar C. Differential Expression of Stem Cell-like Proteins in Normal, Hyperplastic and Dysplastic Oral Epithelium. Journal of Applied Oral Science. 2015; 23(1):79-86.
15. Snider TN, Mishina Y. Cranial Neural Crest Cell Contribution to Craniofacial Formation, Pathology, and Future Directions in Tissue Engineering. National Institutes of Health. 2014; 102(3): 324-332
16. Bunnell B, Flaat M, Gagliardi C, Patel B, Ripoll C. Adipose-derived Stem Cells: Isolation, Expansion and Differentiation. National Institutes of Health. 2008; 45(2): 115-20.
17. Yao S, Pan F, Prpic V, Wise GE. Differentiation of Stem Cells in the Dental Follicle. Journal of Dental Research. 2008; 87(8):767-71.
18. Yanding Z, YiPing C. Bioengineering of a Human Whole Tooth: Progress and Challenge. Cell Regeneration. 2014;3-8.
19. Rocha R. Expanding Therapeutic Boundaries: Stem Cells and Tissue Engineering. Dental Press Journal of Orthodontics. 2011; 16(5):17-9.
20. Mérida I. Bioingeniería y su Aplicación en la Ortodoncia. Revista Latinoamericana de Ortodoncia y Odonotopediatría. 2011.
21. Jasso G, Adalpe B. Bioingeniería Dental ¿El Futuro de la Terapia en Odontología? Revista Asociación Dental Mexicana. 2011; 68(4): 169-74.
22. Hynes K, Menichanin D, Bright R, Ivanovski S, Hutmacher D, Gronthos S, Bartold P. Induced Pluripotent Stem Cells: A New Frontier for Stem Cells in Dentistry. Journal of Dental Research. 2015; 94(11): 1508-15.
23. Margarita D, Diekwisch T, Fincham A, Lau E, McDougall M, Moradian J, Simmer J, Snead M, Slavkin H. Control of Ameloblast Differentiation. Special Review. The International Journal Developmental Biology. 1995; 39(1): 69-72.
24. Zhao H, Chai Y. Stem Cells in Teeth and Craniofacial Bones. Journal of Dental Research. 2015; 94(11): 1495-501.
25. Atalayin C, Tezel H, Dagci T, Karabay Y, Oktem G. Medium Modification with Bone Morphogenetic Protein 2 Addition for Odontogenic Differentiation. Brazilian Oral Research. 2016; 30(1):1-9
26. Carrillo N, García D, Otero L. Aislamiento y Capacidad de Osteodiferenciación de las Células Madre Provenientes del Ligamento Periodontal y Pulpa Dental. Revista CES Odontología. 2015; 28(2): 20-34.
27. Arechaga J. The Tooth as a Model in Organogenesis. An Interview with Professor Harold C. Slavkin. The International Journal of Developmental Biology. 1995; 39(1):13-23.
28. Dabas A, Dabas N, Prabhakar M, Sidhu M. Regenerative Dentistry: A Journey From Stem Cell To A Bio-Tooth. Indian Journal of Dental Sciences. 2013; 5(1).
29. Volponi A, Gentleman E, Fatscher R, Pang Y, Gentleman M, Sharpe P. Composition of Mineral Produced by Dental Mesenchymal Stem Cells. Journal of Dental Research. 2015; 94(11) 1568-74.
30. Volponi A, Kawasaki M, Sharpe P. Adult Human Gingival Epithelial Cells as a Source for Whole-tooth Bioengineering. Research Reports. International & American Associations for Dental Research. 2013; 92(4):329-34.
31. Gao Z, Hu L, Liu G. Bio-Root and Implant-Based Restoration as a Tooth Replacement Alternative. Journal of Dental Research. 2016; 95(6) 642-9.
32. Boke F, Gazioglu C, Akkaya S, Akkaya M. Relationship Between Orthodontic Treatment and Gingival Health: A Restrospective Study. European Journal of Dentistry. 2014; 8(3): 373-80.
33. Alfuriji S, Alhazmi N, Alhamkan N, Ehaideb A, Alruwaithi M, Alkatheeri N, Geevarghese A. The Effect of Orthodontic Therapy on Periodontal Health: A Review of the Literature. International Journal of Dentistry. 2014; 139(4): 413-22.
34. Wise G, Frazier S, Souza R. Cellular, Molecular, and Genetic Determinants of Tooth Eruption. Critical Reviews in Oral Biology & Medicine. 2002; 13(4): 323-34.
35. Ajlan S, Ashri N, Aldahmash A, Alnbaheen M. Osteogenic Differentiation of Dental Pulp Stem Cells Under the Influence of Three Different Materials. BioMed Central Oral Health. 2015; 15:132.
36. Tanimoto K, Sumi K, Yoshioka M, Oki N, Tanne Y, Kato Y, Sugiyama M, Tanne K. Experimental Tooth Movement Into New Bone Area Regenerated by Use of Bone Marrow-Derived Mesenchymal Stem Cells. Cleft Palate-Craniofacial Journal. 2015; 52(4): 386-94
37. Rabie M, Hagg U. Factors Regulating Mandibular Condylar Growth. Hong Kong SAR, China. American Journal of Orthodontics and Dentofacial Orthopedics. 2002; 122(4): 401-409.
38. Moss M. The Functional Matrix Hypothesis Revisited. 4. The Epigenetic Antithesis and the Resolving Synthesis. American Journal of Orthodontics and Dentofacial Orthopedics. 1997; 112 (4).
39. Tanaka E, Sato S. Longitudinal Alteration of the Occlusal Plane and Development of Different Dentoskeletal Frames During Growth. American Journal of Orthodontics and Dento-facial Orthopedics. 2008; 134(5): 410-417.
40. Rabie A, Wong L, Tsai M. Replicating Mesenchymal Cells in the Condyle and the Glenoid Fossa During Mandibular Forward Positioning. American Journal of Orthodontics and Dentofacial Orthopedics. 2003; 123(1): 49-57.
41. Willems N, Langenbach G, Everts V, Zentner A. The Microstructural and Biomechanical Development of the Condylar Bone: a Review. European Journal of Orthodontics. 2013; 36(4): 479-85.
42. Alhadlaq A, Mao J. Tissue-engineered Neogenesis of Human-shaped Mandibular Condyle from Rat Mesenchymal Stem Cells. Journal of Dental Research. 2003; 82(12): 951-956.
43. Kanekawa Mika, Shimizu Noriyoshi. Agerelated Changes on Bone Regeneration in Midpalatal Suture During Maxillary Expansion in the rat. American Journal of Orthodontics and Dentofacial Orthopedics. 1998; 114(6): 646-53.
44. Dai Juan, Rabie M. Gene Therapy to Enhance Condylar Growth Using rAAVVEGF. Angle Orthodontist. 2008; 78(1).
45. Mao J, Wang X, Kopher R. Orthopedic Implications. Angle Orthodontist, 2003; 73(2): 89-94.
46. Mao J. Mechanobiology of Craniofacial Sutures. Journal of Dental Research. 2002; 81(12): 810-6.
47. Hong L, Mao J. Tissue-engineered Rabbit Cranial Suture from Autologous Fibroblasts and BMP2. Journal of Dental Research. 2004; 83(10): 751-6.
48. Shih S, Kyung H, Buschang P. Continuous Forces are More Effective than Intermittent Forces in Expanding Sutures. European Journal of Orthodontics. 2010; 32(4): 371-80.
49. Ekizer A, Yalvac M, Uysal T, Sonmez M, Sahin F. Bone Marrow Mesenchymal Stem Cells Enhance Bone Formation in Orthodontically Expanded Maxillae in Rats. Angle Orthodontist. 2015; 85(6): 1084-5.
50. Osman A, Gnanasegaran N, Govindasamy V, Kathivaloo P, Wen A, Musa S, Abu K. Basal Expression of Growth-Factor-Associated Genes in Periodontal Ligament Stem Cells Reveals Multiple Distinctive Pathways. International Endodontic Journal. 2014; 47(7): 639-51.
51. Athanassiou-Papaefthymiou M, Papagerakis P, Papagerakis S. Isolation and Characterization of Human Adult Epithelial Stem Cells from the Periodontal Ligament. Journal of Dental Research. 2015; 94(11):1591-1600.
2. Li J, Liu D, Zhang F, Wang F, Zhang W, Zhang Z. Human Dental Pulp Stem Cell is a Promising Autologous Seed Cell for Bone Tissue Engineering. Chinese Medical Journal. 2011;124(23):4022-4028
3. Yelick PC, Vacanti J. Bioengineered Teeth from Tooth Bud Cells. The Dental Clinics of North America. 2006; 50(2):191-203.
4. Wise GE, King GJ. Mechanisms of Tooth Eruption and Orthodontic Tooth Movement. Journal of Dental Research. 2008; 87(5):414-34
5. Hiroshi E, Wataru S, Masahiro N, Ikiru A,
Kentaro A. Stem Cells in Dentistry – Part I: Stem Cell Sources: Review. Journal of Prosthodontic Research. 2012;56: 151-65.
6. Hiroshi E, Wataru S, Masahiro N, Ikiru A, Kentaro A. Stem cells in dentistry – Part II: Clinical Applications: Review. Journal of Prosthodontic Research. 2012;16 :229-48.
7. Muñoz W, Trainor P. Neural Crest Cell Evolution: How and When Did a Neural Crest Cell Become a Neural Crest Cell. Current Topics in Developmental Biology. 2015; 111:3-26.
8. Noce, M; Mele, K; Tirino, V; Paino, F. Rosa, A; Naddeo, P; Papagerakis, P; Papaccio, G; Desiderio V. Neural Crest Stem Population in Craniomaxillofacial Development and Tissue Repair. European Cells and Materials. 2014; 28:348-57.
9. Mohanty P, Prasad N, Sahoo N, Kumar G, Mohanty D, Sah S. Reforming Craniofacial Orthodontics Via Stem Cells. Journal of International Society of Preventive and Community Dentistry. 2015; 5(1):13-8.
10. Parada C. Evolución y Desarrollo Facial: Perspectiva Molecular. Universitas Odontológica. 2009; 28(61): 75-85.
11. Hall BK. The Induction of Neural Crestderived Cartilage and Bone by Embryonic Epithelia: an Analysis of the Mode of Action of an Epithelial-mesenchymal Interaction. Journal of Embryology and Experimental Morphology. 1981; 64:305-320
12. Ten R. The Experimental Investigation of Odontogenesis. Journal Developmental Biology. Faculty of Dentistry. 1995; 39:5-11.
13. Kushnerev E, Yates J. Stem Cells in Dentistry – A New Era on the Horizon? Faculty Dental Journal. 2016; 7(2):64-7.
14. Mohammed S, Siar C. Differential Expression of Stem Cell-like Proteins in Normal, Hyperplastic and Dysplastic Oral Epithelium. Journal of Applied Oral Science. 2015; 23(1):79-86.
15. Snider TN, Mishina Y. Cranial Neural Crest Cell Contribution to Craniofacial Formation, Pathology, and Future Directions in Tissue Engineering. National Institutes of Health. 2014; 102(3): 324-332
16. Bunnell B, Flaat M, Gagliardi C, Patel B, Ripoll C. Adipose-derived Stem Cells: Isolation, Expansion and Differentiation. National Institutes of Health. 2008; 45(2): 115-20.
17. Yao S, Pan F, Prpic V, Wise GE. Differentiation of Stem Cells in the Dental Follicle. Journal of Dental Research. 2008; 87(8):767-71.
18. Yanding Z, YiPing C. Bioengineering of a Human Whole Tooth: Progress and Challenge. Cell Regeneration. 2014;3-8.
19. Rocha R. Expanding Therapeutic Boundaries: Stem Cells and Tissue Engineering. Dental Press Journal of Orthodontics. 2011; 16(5):17-9.
20. Mérida I. Bioingeniería y su Aplicación en la Ortodoncia. Revista Latinoamericana de Ortodoncia y Odonotopediatría. 2011.
21. Jasso G, Adalpe B. Bioingeniería Dental ¿El Futuro de la Terapia en Odontología? Revista Asociación Dental Mexicana. 2011; 68(4): 169-74.
22. Hynes K, Menichanin D, Bright R, Ivanovski S, Hutmacher D, Gronthos S, Bartold P. Induced Pluripotent Stem Cells: A New Frontier for Stem Cells in Dentistry. Journal of Dental Research. 2015; 94(11): 1508-15.
23. Margarita D, Diekwisch T, Fincham A, Lau E, McDougall M, Moradian J, Simmer J, Snead M, Slavkin H. Control of Ameloblast Differentiation. Special Review. The International Journal Developmental Biology. 1995; 39(1): 69-72.
24. Zhao H, Chai Y. Stem Cells in Teeth and Craniofacial Bones. Journal of Dental Research. 2015; 94(11): 1495-501.
25. Atalayin C, Tezel H, Dagci T, Karabay Y, Oktem G. Medium Modification with Bone Morphogenetic Protein 2 Addition for Odontogenic Differentiation. Brazilian Oral Research. 2016; 30(1):1-9
26. Carrillo N, García D, Otero L. Aislamiento y Capacidad de Osteodiferenciación de las Células Madre Provenientes del Ligamento Periodontal y Pulpa Dental. Revista CES Odontología. 2015; 28(2): 20-34.
27. Arechaga J. The Tooth as a Model in Organogenesis. An Interview with Professor Harold C. Slavkin. The International Journal of Developmental Biology. 1995; 39(1):13-23.
28. Dabas A, Dabas N, Prabhakar M, Sidhu M. Regenerative Dentistry: A Journey From Stem Cell To A Bio-Tooth. Indian Journal of Dental Sciences. 2013; 5(1).
29. Volponi A, Gentleman E, Fatscher R, Pang Y, Gentleman M, Sharpe P. Composition of Mineral Produced by Dental Mesenchymal Stem Cells. Journal of Dental Research. 2015; 94(11) 1568-74.
30. Volponi A, Kawasaki M, Sharpe P. Adult Human Gingival Epithelial Cells as a Source for Whole-tooth Bioengineering. Research Reports. International & American Associations for Dental Research. 2013; 92(4):329-34.
31. Gao Z, Hu L, Liu G. Bio-Root and Implant-Based Restoration as a Tooth Replacement Alternative. Journal of Dental Research. 2016; 95(6) 642-9.
32. Boke F, Gazioglu C, Akkaya S, Akkaya M. Relationship Between Orthodontic Treatment and Gingival Health: A Restrospective Study. European Journal of Dentistry. 2014; 8(3): 373-80.
33. Alfuriji S, Alhazmi N, Alhamkan N, Ehaideb A, Alruwaithi M, Alkatheeri N, Geevarghese A. The Effect of Orthodontic Therapy on Periodontal Health: A Review of the Literature. International Journal of Dentistry. 2014; 139(4): 413-22.
34. Wise G, Frazier S, Souza R. Cellular, Molecular, and Genetic Determinants of Tooth Eruption. Critical Reviews in Oral Biology & Medicine. 2002; 13(4): 323-34.
35. Ajlan S, Ashri N, Aldahmash A, Alnbaheen M. Osteogenic Differentiation of Dental Pulp Stem Cells Under the Influence of Three Different Materials. BioMed Central Oral Health. 2015; 15:132.
36. Tanimoto K, Sumi K, Yoshioka M, Oki N, Tanne Y, Kato Y, Sugiyama M, Tanne K. Experimental Tooth Movement Into New Bone Area Regenerated by Use of Bone Marrow-Derived Mesenchymal Stem Cells. Cleft Palate-Craniofacial Journal. 2015; 52(4): 386-94
37. Rabie M, Hagg U. Factors Regulating Mandibular Condylar Growth. Hong Kong SAR, China. American Journal of Orthodontics and Dentofacial Orthopedics. 2002; 122(4): 401-409.
38. Moss M. The Functional Matrix Hypothesis Revisited. 4. The Epigenetic Antithesis and the Resolving Synthesis. American Journal of Orthodontics and Dentofacial Orthopedics. 1997; 112 (4).
39. Tanaka E, Sato S. Longitudinal Alteration of the Occlusal Plane and Development of Different Dentoskeletal Frames During Growth. American Journal of Orthodontics and Dento-facial Orthopedics. 2008; 134(5): 410-417.
40. Rabie A, Wong L, Tsai M. Replicating Mesenchymal Cells in the Condyle and the Glenoid Fossa During Mandibular Forward Positioning. American Journal of Orthodontics and Dentofacial Orthopedics. 2003; 123(1): 49-57.
41. Willems N, Langenbach G, Everts V, Zentner A. The Microstructural and Biomechanical Development of the Condylar Bone: a Review. European Journal of Orthodontics. 2013; 36(4): 479-85.
42. Alhadlaq A, Mao J. Tissue-engineered Neogenesis of Human-shaped Mandibular Condyle from Rat Mesenchymal Stem Cells. Journal of Dental Research. 2003; 82(12): 951-956.
43. Kanekawa Mika, Shimizu Noriyoshi. Agerelated Changes on Bone Regeneration in Midpalatal Suture During Maxillary Expansion in the rat. American Journal of Orthodontics and Dentofacial Orthopedics. 1998; 114(6): 646-53.
44. Dai Juan, Rabie M. Gene Therapy to Enhance Condylar Growth Using rAAVVEGF. Angle Orthodontist. 2008; 78(1).
45. Mao J, Wang X, Kopher R. Orthopedic Implications. Angle Orthodontist, 2003; 73(2): 89-94.
46. Mao J. Mechanobiology of Craniofacial Sutures. Journal of Dental Research. 2002; 81(12): 810-6.
47. Hong L, Mao J. Tissue-engineered Rabbit Cranial Suture from Autologous Fibroblasts and BMP2. Journal of Dental Research. 2004; 83(10): 751-6.
48. Shih S, Kyung H, Buschang P. Continuous Forces are More Effective than Intermittent Forces in Expanding Sutures. European Journal of Orthodontics. 2010; 32(4): 371-80.
49. Ekizer A, Yalvac M, Uysal T, Sonmez M, Sahin F. Bone Marrow Mesenchymal Stem Cells Enhance Bone Formation in Orthodontically Expanded Maxillae in Rats. Angle Orthodontist. 2015; 85(6): 1084-5.
50. Osman A, Gnanasegaran N, Govindasamy V, Kathivaloo P, Wen A, Musa S, Abu K. Basal Expression of Growth-Factor-Associated Genes in Periodontal Ligament Stem Cells Reveals Multiple Distinctive Pathways. International Endodontic Journal. 2014; 47(7): 639-51.
51. Athanassiou-Papaefthymiou M, Papagerakis P, Papagerakis S. Isolation and Characterization of Human Adult Epithelial Stem Cells from the Periodontal Ligament. Journal of Dental Research. 2015; 94(11):1591-1600.
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